STUDY ON THE EXPRESSION OF KAI1 TUMOR METASTASIS SUPPRESSOR GENE IN CERVICAL CARCINOMA AND THE CORRELATION

Objective To detect the expression of KAI1/CD82 metastasis suppressor gene in cervical carcinoma and the correlation with pathologic features.MethodsImmunohistochemistry was used to detect the expression of KAI1/CD82 gene in formalin-fixed,paraffin-embedded specimens of 20 normal cervical epithelium,15 cervical carcinoma in situ,70 invasive cervical carcinoma as well as 29 lymph node metastases. Correlation of expression of KAI1 gene with pathologic factors were statistically analyzed.ResultsThe protein expression of KAI1/CD82 in tumor cells was down-regulation in invasive carcinoma and carcinoma in situ compared to that in controls(P﹤0.05);the protein expression of KAI1 was not correlated with clinical stage,pathological subtype,lymph node metastasis,depth of vessel infiltration and cervical interstitium and muscular layer invasion of cervical carcinoma(P﹥0.05). But its expression significantly decreased in poorly differentiated tumors compared to that of well and moderately differentiated tumors. KAI1 also expressed in lymph node metastases,but there was no statistically significant difference between them with expression in situ.ConclusionThe KAI1/CD82 metastasis suppressor gene may not be a main factor in invasion and metastasis of cervical carcinoma.