Neurogenesis in the brain

Neurogenesis is sustained throughout adulthood in the mammalian brain due to the proliferation and differentiation of adult neural progenitor cells found in the subventricular zone of the lateral ventricles and subgranular zone of the dentate gyrus.This review covers recent findings that elucidate different aspects of regulation of neurogenesis,including proliferation,migration and differentiation into mature neurons and functional integration into the existing neural circuits.Furthermore,this review also discusses the effects of pathological conditions on adult neurogenesis in both rodent models and human patients as well as some of the potential problems or limitations in neurogenesis research,which may shed some light on developing novel research strategies for replacement treatment of neurological disorders.