Evaluation of glomerular filtration rate in people greater than 60 years old in Jiangsu China

Objective To compare the values reported by four methods of original abbreviated MDRD equation(eGFRa),the modified abbreviated MDRD equation(c-aGFR3),the refitting MDRD equation(M-MDRD-GFR) and the Chronic Kidney Disease Epidemiology Collaboration(CKD-EPI) creatinine equation in estimation of glomerular filtration rate(GFR) in the people greater than 60 years old.Methods A total of 1404 residents aged 60 to 94 years old was randomly recruited from the community population in Jiangsu province.The values of GFR were estimated in three age groups and three complicated diseases groups.Results GFR estimated by CKD-EPI equation was decreased as age increased(P0.01).The patients with hypertention,diabetes and hyperuricemia showed a certain decrease in GFR estimated by all equations.c-aGFR3,M-MDRD-GFR and CKD-EPI equations revealed a significant decrease of GFR in the people with hyperuricemia than in healthy people.The agreements in Kappa values on GFR estimation between c-aGFR3,M-MDRD-GFR,CKD-EPI formulas and eGFRa equation were very good,which were 0.775,0.883,0.912,respectively(P0.01).There was a close correlation in GFR estimated by CKD-EPI equation and simplified MDRD equation with higher accuracy and less bias.Conclusion The GFR estimated by all four equations has a tendency of decrease with aging in the elder population in Jiangsu,of which CKD-EPI equation may be more suitable.