Effect of Glutamine Enteral Nutrition on Nutritional Status and Immunological Function in Patients with Colorectal Cancer after Operation

Objective To investigate the effect of glutamine enteral nutrition( EN) on nutritional status and immunological function in patients with colorectal cancer after operation. Methods Sixty-six patients with colorectal cancer after operation were randomly divided into 3 groups according to the random number table,with 22 cases in each group,the glutamine enteral nutrition group( Gln group) was given enteral nutrition with glutamine nutrition liquid,the conventional enteral nutrition group( EN group) was given normal enteral nutrition,the parenteral nutrition group( PN group) was given normal parenteral nutrition. The treatment lasted for 10 days in 3 groups. The nutrition,immune parameters and operation conditions of patients in 3 groups were observed one day before operation,1,10 days after operation,respectively. Results Ten days after operation,the body weight( BW),triceps skin-fold thickness( TSF),arm muscle circumference( AMC),albumin( ALB) level in Gln group were superior to those in EN and PN groups( all P 0. 05),the level of total protein( TP) was lower than that in EN group( P 0. 05); Ten days after operation,the levels of CD4+,CD4+/ CD8+,IgA in Gln group were significantly higher than those in EN group( all P 0.05),the level of CD8+was significantly lower than that in EN group( P 0. 05),and the levels of CD4+、CD4+/ CD8+were significantly higher than those in PN group( all P 0. 05). There was no significant difference in the anal exhaust time,clearing time and incidence of complications among 3 groups( P 0. 05),while the hospital stay in Gln,EN groups was longer than that in PN group( P 0. 05). Conclusion Glutamine enteral nutrition plays a certain role in the improvement of nutrition state and immune function in patients with colorectal cancer after operation.