The expression of STAT 4、STAT 6 in the decidua of women with unexplained recurrent spontaneous abortion

Objective To investigate the roles of transcription factor STAT 4、STAT 6 in the pathogenesis of unexplained recurrent spontaneous abortion(URSA)at the fetalmaternal interface.Methods The expression and distribution of STAT 4、STAT 6 were examined By immunohistochemistry on the decidua obtained from 20 women with URSA and 20 normal pregnant wonmen respectively.Results The expression of STAT 4、STAT 6 were both positive and located mainly in the decidua cells.The expression of STAT 4 positive cells in URSA group(144.70±7.71)were significantly higher than the controls(120.53±14.86).The expression of STAT 6 positive cells in URSA group(124.30±5.35)were significantly lower than the controls(152.10±2.10).Numbers of cells expressing STAT 4 negatively correlated significantly with STAT 6 positive cell numbers in decidua cells.Conclusion The results demonstrated that upregulated expression of STAT 4 and downregulated expression of STAT6 are found in the decidua cells of wonmen with URSA,Imbalance of STAT4/STAT6 might interfere with type 1 helper T cell(Th1)type 2 helper T cell(Th2)differentiation.STAT 4、STAT 6 may be one of the major causes of URSA.