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Clinical study of low dose and short term rhG-CSF on neutropenia induced by chemotherapy

Jie Ya

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Abstract

Objective To Study the effect of low dose and rh GCSF(Recombinant Human Granulocyte Colony Stimulating Factor) on leukepenia and nenutropenia induced by chemotherapy in a randomized clinical trial.Methods The total patients entrolled were 108 in number and were randominzed into A B and C group(36patients each).In group A rhG CSF was given for 3 day at the dose of 75μg/dS.C. In group B rh GCSF was given for 6 days at the dose of 75μg/d S.C I n group C rhG CSF was given for 5 day at the dose of 75μg/d S.C. Results Iow dose and short term rhG CSF remarkably increased the count of WBC and ANC and lowored the number of days with WBC4 0×10 9/l,ANC50% by cancer chemotherapy with minimal side effects.In group B is was higher than A.C group for the effect.Conclusion Low dose and short term rhG CSF were effective,B group had the hest effect.

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Objective To Study the effect of low dose and rh GCSF(Recombinant Human Granulocyte Colony Stimulating Factor) on leukepenia and nenutropenia induced by chemotherapy in a randomized clinical trial.Methods The total patients entrolled were 108 in number and were randominzed into A B and C group(36patients each).In group A rhG CSF was given for 3 day at the dose of 75μg/dS.C. In group B rh GCSF was given for 6 days at the dose of 75μg/d S.C I n group C rhG CSF was given for 5 day at the dose of 75μg/d S.C. Results Iow dose and short term rhG CSF remarkably increased the count of WBC and ANC and lowored the number of days with WBC4 0×10 9/l,ANC50% by cancer chemotherapy with minimal side effects.In group B is was higher than A.C group for the effect.Conclusion Low dose and short term rhG CSF were effective,B group had the hest effect.

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Available abstract

Objective To Study the effect of low dose and rh GCSF(Recombinant Human Granulocyte Colony Stimulating Factor) on leukepenia and nenutropenia induced by chemotherapy in a randomized clinical trial.Methods The total patients entrolled were 108 in number and were randominzed into A B and C group(36patients each).In group A rhG CSF was given for 3 day at the dose of 75μg/dS.C. In group B rh GCSF was given for 6 days at the dose of 75μg/d S.C I n group C rhG CSF was given for 5 day at the dose of 75μg/d S.C. Results Iow dose and short term rhG CSF remarkably increased the count of WBC and ANC and lowored the number of days with WBC4 0×10 9/l,ANC50% by cancer chemotherapy with minimal side effects.In group B is was higher than A.C group for the effect.Conclusion Low dose and short term rhG CSF were effective,B group had the hest effect.

Key concepts: Chemotherapy, Granulocyte colony-stimulating factor, Medicine, Neutropenia, Gastroenterology, Internal medicine, Group B, Granulocyte

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