2013•Academic Journal of Chinese PLA Medical SchoolRequires access
OXA genotypes of imipenem-resistant Acinetobacter baumannii
Xin Liu
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Abstract
Objective To provide the scientific evidence for the control of hospital infection with imipenem-resistant Acinetobacter baumannii and its epidemiological survey by investigating the prevalence of its OXA genotypes in our hospital.Methods The OXA genetypes of 68 imipenem-resistant Acinetobacter baumannii strains isolated in our hospital from April 2010 to December 2010 were analyzed by multiplex PCR.Results Of the 68 isolated imipenem-resistant Acinetobacter baumannii strains,7 were OXA51 positive gene with a detection rate of 10.29%,60 were OXA-51 and OXA-23 positive gene with a detection rate of 88.24%,and 1 was OXA-51 and OXA-58 positive gene with a detection rate of 1.47%.No OXA-24 gene was detected.Conclusion OXA51+OXA-23 genotype is the popular OXA genetype of imipenem-resistant Acinetobacter baumannii in our hospital,indicating that it is the most important mechanism underlying the resistance of imipenem-resistant Acinetobacter baumannii to carbapenemases in our hospital,and laboratory should strengthen its monitoring of enzyme-producing strains.