Study on the Change of Leucocyte Classification in Leucocyte Decreasing Rats Induced by Cyclophosphamide

Objective To observe the change of leucocyte classification in leucocyte decreasing rats induced by cyclophosphamide.Methods Cyclophosphamide (30/kg) was injected into rats' abdominal cavity for five days,while in the control group,isovolumic normal saline was injected.Results The total of leucocyte in peripheral blood decreased markedly( p 0 01),which maintained for 15 days after stopping dosing.In the mean time,band\|form granulocyte increased (p0.01),even if stopping dosing 15 days;segmented granulocyte reduced (p0.01),but it returned after stopping dosing.Cyclophosphamide had no effect on lymphocyte.Conclusion Cyclophosphamide caused the change of leucocyte count and its classification, with band\|form granulocyte increased and segmented granulocyte reduced,which could be used as experimental indications.