2013•Chinese Journal of Health Laboratory TechnologyRequires access

The relationship of disseminated intravascular coagulation(DIC) between coagulation,fibrinolysis changes and prognosis

Deng Ming-fen

Abstract

Objective:To investigate the relationship of disseminated intravascular coagulation(DIC) with coagulation,fibrinolysis changes and prognosis in patients.Methods:Two hundred and forty patients were divided into survival group and death group to observe the changes of platelet(PLT) count,prothrombin time(PT),activated partial thromboplastin time(APTT),fibrinogen(Fbg),fibrin(fibrinogen) degradation products(FDP),protamine paracoagulation(3P) test and D-dimer(D-Dimer).Results:The positive rate of D-Dimer in DIC patients is the highest,the coagulation and fibrinolysis in death group were significantly higher than those in the survival group; It was found that the DIC score in death group was rising and/ or maintained at a high level by dynamic monitoring on 49 DIC patients.Conclusion:Dynamical monitoring on coagulation and fibrinolysis of DIC patients,combined with the score,was important to evaluate the pathogenetic condition and prognosis.

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Key concepts: Fibrinolysis, Fibrinogen, Partial thromboplastin time, Disseminated intravascular coagulation, Medicine, Prothrombin time, Coagulation, D-dimer