Efficacy Comparison of Late Course Accelerated Hyper Fractionation Radiotherapy and Plus Chemotherapy for Advanced Esophageal Carcinoma

Objective To compare the treatment effects and toxicity of late course accelerated hyper fractionation radiotherapy(LCAFR),LCAFR plus concurrent chemotherapy(LCAFR+C) on esophageal cancer.Methods 162 patients of esophageal carcinoma were randomly divided into two groups.In the LCAFR group,80 patients first recevied 30 Gy by routine fractionation,followed by 33 Gy,1.5 Gy twice daily,at more than 6 hours' interval,5 days per week,total doses were 63 Gy.In the combined group,82 patients receive two cycle dayly.Curing formulas were 20 mg DDP and 500 mg 5-Fu plus 0.2 CF for five consecutive days as one cycle in the first and fourth weeks.Results The 1-,2-,3-year survival rates of the combined and LCAFR groups were 79.3%,(54.8%),43.9% and 53.8%,35.0%,25.0%(χ~2=10.33,P0.01;χ~2=5.61,P0.05;χ~2=5.65,P0.05).Threr were statistical significance in the two groups.The main death cause of two groups was local recurrence and uncontrolled of tumor.The LCAFR+C group was lower(50.0%,18/36) than the LCAFR groups(75.0%,45/60).There was statistical significance in the two groups(χ~2=6.18,P0.05).The acute toxic effect was severer in the LCAFR+C group than in the LCAFR group in Ⅲ degree digestive system and hematopoietic system.There were no significant differences in the two groups.Conclusion The esophagus carcinoma patients's survial rate of LCAFR+C group was significant higher than the LCAFR group.Toxicity of patient was increasing but the patients could tolleats.