Efficacy of parecoxib for preemptive analgesia after laparoscopic cholecystectomy

Objective To evaluate effects of parecoxib for preemptive analgesia in patients under-going laparoscopic cholecystectomy (LC).Methods Eighty patients undergoing LC were randomly divided into two groups:A and B.Patients in Group A (n=40) received parecoxib 40mg before induction:patients in Group B (n=40) received the same doses after skin closure.A standardized general anesthetic was used.All patients were started on fentanil (i.v.1.0μg/kg) analgesia when awake after tracheal extubation.The effectiveness was assessed postoperatively using the visual analogue scale (VAS) at 0、1、2、4、8、12、24hours after surgery,and by calculating the total analgesic consumption of fentanil in the first 24 hours following operation.Time to first analgesic request,vital signs and side effects were also recorded.Results Patients in group A reported significantly lower pain scores(P0.05)at all time intervals compared to group B.There were significantly fewer patients in the preemptive group than comparative group who required rescue analgesic with in the first 24 hours (P0.05).Mean time to first analgesic request was also significantly longer in the preemptive group (P0.05).Conclusion Parecoxib administered preemptively appears to improve the quality of postoperative analgesia and lead to reduced consumption of opioid analgesics postoperatively in patients undergoing LC.