ScholarLens Back to search
2009•Zhongguo laonianxue zazhiRequires access

The expression of Nogo-A after cerebral ischemia-reperfusion injury and its significance

Gao Xiao

Open publisher page 0 citations

Abstract

Objective To study the expression of Nogo-A in cerebral white matter after focal cerebral ischemia-reperfusion(I/R) in rats,and explore the relationship between Nogo-A and cerebral white matter lesions after ischemia. Methods Sprague-Dawley male rats were subjected to 2 h of middle cerebral artery occlusion (MCAO). Relative quantification PCR(RQ-PCR) was performed to examine the expressions of Nogo-A gene at different reperfusion time. Results The expression level of Nogo-A gene in the white matter was decreased in 1 d group(P0.05 vs sham group),and was the weakest in 7 d group. It was increased in 14~21 d group,and in 21 d the expression level was still lower than that of sham group(P0.001). Conclusions Nogo-A expreesion has dynamic changes in the white matter after focal cerebral I/R. Nogo-A could be as one of the targets for neuroprotective therapy after cerebral ischemia.

About this research paper

What this paper is about

Objective To study the expression of Nogo-A in cerebral white matter after focal cerebral ischemia-reperfusion(I/R) in rats,and explore the relationship between Nogo-A and cerebral white matter lesions after ischemia. Methods Sprague-Dawley male rats were subjected to 2 h of middle cerebral artery occlusion (MCAO). Relative quantification PCR(RQ-PCR) was performed to examine the expressions of Nogo-A gene at different reperfusion time. Results The expression level of Nogo-A gene in the white matter was decreased in 1 d group(P0.05 vs sham group),and was the weakest in 7 d group. It was increased in 14~21 d group,and in 21 d the expression level was still lower than that of sham group(P0.001). Conclusions Nogo-A expreesion has dynamic changes in the white matter after focal cerebral I/R. Nogo-A could be as one of the targets for neuroprotective therapy after cerebral ischemia.

Why it matters

A significance statement is not available in the OpenAlex record.

Key contribution

A contribution statement is not available in the OpenAlex record.

Method / approach

Method details are not available in the OpenAlex metadata.

Main findings

Findings are not separately available in the OpenAlex metadata.

Limitations

Limitations are not available in the OpenAlex metadata.

Applications

Application details are not available in the OpenAlex metadata.

Available abstract

Objective To study the expression of Nogo-A in cerebral white matter after focal cerebral ischemia-reperfusion(I/R) in rats,and explore the relationship between Nogo-A and cerebral white matter lesions after ischemia. Methods Sprague-Dawley male rats were subjected to 2 h of middle cerebral artery occlusion (MCAO). Relative quantification PCR(RQ-PCR) was performed to examine the expressions of Nogo-A gene at different reperfusion time. Results The expression level of Nogo-A gene in the white matter was decreased in 1 d group(P0.05 vs sham group),and was the weakest in 7 d group. It was increased in 14~21 d group,and in 21 d the expression level was still lower than that of sham group(P0.001). Conclusions Nogo-A expreesion has dynamic changes in the white matter after focal cerebral I/R. Nogo-A could be as one of the targets for neuroprotective therapy after cerebral ischemia.

Key concepts: Ischemia, White matter, Neuroprotection, Medicine, Occlusion, Middle cerebral artery, Reperfusion injury, Internal medicine

Related papers

Related paper 1Related paper 2Related paper 3
Back to paper searchBrowse research topicsOriginal source
The expression of Nogo-A after cerebral ischemia-reperfusion injury and its significance — Research Paper | ScholarLens