The Experimental Study of Enhancing Fracture Healing of ZhuangJinXuGuTang

Objective To study the effect of ZhuangJinXuGuTang on enhancing the femoral fracture healing in experimental rats. Methods Total of 50 adult healthy male Wistar rats were established fracture models by cutting femur at middle point of rats, and treated with ZhuangJinXuGuTang. The fracture healing condition was observed by X-ray, and the pathological conditions of fracture healing were detected by HE staining. Results After treatment 7 days, the local swelling at femoral fracture subsided gradually. The fibrous callus tissue began forming to reduce the fracture line at X-ray film, and the fibroblast and osteoblast increased significantly at the fracture-end. At treatment 14 days, the movement of fractured limb recovered successfully, more fibrous callus tissue forming and calcium mineral deposited at the fracture-end to remove the fracture line at X-ray film, and more fibrous, cartilaginous and osseous callus tissues forming to enhance the fracture healing. Conclusion ZhuangJinXuGuTang could enhance the fracture healing in experimental facture rats.