Effect comparison of glucocorticoids for acute exacerbation of COPD

Objective To compare the blood points off change and blood glucose affect of systemic steroids and hormone therapy atomization for acute exacerbation of COPD( AECOPD). Methods 178 patients with AECOPD were randomly divided into observation group and control group,each of 89 cases. Observation group received budesonide inhalation therapy,control group was given intravenous methylprednisolone therapy. Compared the oxygen tension( Pa O2),arterial carbon dioxide( Pa CO2),p H value and fasting glucose levels before and after treatment of two groups. Results After treatment,the Pa O2 of observation group was higher than that before treatment,the Pa CO2 of observation group was lower than that before treatment,the differences were statistically significant( P 0. 01). The difference of p H value and the fasting blood glucose before and after treatment of observation group were not statistically significant( P 0. 05). After treatment the Pa O2 of control group was higher than before treatment,fasting blood glucose was higher than before treatment,the differences were statistically significant( P 0. 05). The difference of Pa CO2 and p H value of control group before and after treatment were not statistically significant( P 0. 05). Conclusion In patients with AECOPD,local inhaled corticosteroid treatment is better than that of systemic medication,and less side effects.