Research on expression of CXCR4 and CCR7 in non small cell lung cancer cells

Objective To explore the difference between CXCR4 and CCR7 in expression in NSCLC,and further to explore the role of CXCR4 and CCR7 in regional lymph nodes metastasis in NSCLC.Methods SABC immunohistochemical staining was used.The specimens were 41 cases of primary tumor tissues of NSCLC,25 cases of regional metastasized lymph nodes in 41,and 20 cases of normal lung tissues.Results In primary tumor cells,the positive rate of the expression of CXCR4 was higher than that of CCR7(92.68% vs 68.29%;P0.05).Both expression were higher than that in normal lung tissues(P0.05).And there were significant correlation between the CCR7 expression and TNM stage,as well as the regional lymph nodes metastasis occurring(P0.05).In regional metastasized lymph nodes,the positive rate of CXCR4 and CCR7 were 96% and 84% in cancer cells respectively(P0.05).Conclusion CXCR4 and CCR7 play roles in inducing target metastasis of cancer cells to regional lymph nodes.To NSCLC,CCR7 is more important than CXCR4.