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2000•Unpublished venueRequires access

Tumor Necrosis Factor-α Expression in Ischemic Neurons

Kang Liu

Open publisher page 69 citations

Abstract

Objective To explore mechanism of TNF α expression on cerebral ischemia damage in rats.Methods Using RT PCR technique in detecting. Results TNF α mRNA expression after MCAO was changed with time.TNF αmRNA was elevated at 1h only in the ischemic cortex,significantly elevated at 3h and 5d,with peak expression at 12h. Conclusion TNF αmRNA expression in cerebral ischemia might contribute to important factor in focal stroke.

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What this paper is about

Objective To explore mechanism of TNF α expression on cerebral ischemia damage in rats.Methods Using RT PCR technique in detecting. Results TNF α mRNA expression after MCAO was changed with time.TNF αmRNA was elevated at 1h only in the ischemic cortex,significantly elevated at 3h and 5d,with peak expression at 12h. Conclusion TNF αmRNA expression in cerebral ischemia might contribute to important factor in focal stroke.

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Available abstract

Objective To explore mechanism of TNF α expression on cerebral ischemia damage in rats.Methods Using RT PCR technique in detecting. Results TNF α mRNA expression after MCAO was changed with time.TNF αmRNA was elevated at 1h only in the ischemic cortex,significantly elevated at 3h and 5d,with peak expression at 12h. Conclusion TNF αmRNA expression in cerebral ischemia might contribute to important factor in focal stroke.

Key concepts: Ischemia, Tumor necrosis factor alpha, Messenger RNA, Tumor necrosis factor α, Necrosis, Medicine, Real-time polymerase chain reaction, Pathology

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