Different time amlodipine non-dipper hypertensive patients blood pressure

Objective To explore the different time amlodipine non-dipper hypertensive patients with circadian rhythm of blood.Methods By ambulatory blood pressure monitoring,select the 84 cases of non-dipper hypertensive patients were randomly divided into two groups:early morning medication group(n=42) and bedtime medication group(n=42),respectively,7:00~9:00 and 20:00~22:00 amlodipine 5 mg,12 weeks of continuous treatment.Ambulatory blood pressure monitoring before and after administration were observed early morning medication group and bedtime medication on the circadian rhythm in non-dipper hypertensive patients.Results Morning medication group and bedtime medication group 24 h after treatment the mean systolic and diastolic blood pressures were significantly lower(P0.05),compared with early morning medication group before going to bed the treated group of night-time systolic and diastolic blood pressure decreased significantly(P0.05),and bedtime blood pressure medication group of non-dipper hypertensive model significantly improved in both groups were 16.7% and 47.6%(P0.01).Conclusion On the non-dipper hypertensive patients to take at bedtime amlodipine not only can effectively lower blood pressure,can also improve the abnormal circadian rhythm of blood,in order to better protect the target organ.