Anaphylactoid purpura following cefoperazone sodium: one case report

A 70-years-old woman with acute cholecystitis was admitted into the hospital.She was administered with intravenous infusion of clindamycin(600mg,qd) and cefoperazone sodium(2.0g,bid) for the treatment of infection.Skin rash accompanied by subcutaneous bleeding on left arm was found next day.Cefoperazone sodium was withdrawn for considering the association with this drug.When the patient was reexposed to cefoperazone sodium for controlling the infection one week later,she presented systemic skin rash,and the PLT decreased below normal limits.The diagnosis was anaphylactoid purpura.Cefoperazone sodium was stopped immediately.Next day her Cr increased from 205μmol·L-1 to 464μmol·L-1,and the BUN increased from 13.5mmol·L-1 to 23.6mmol·L-1.For anti-allergic therapy,she was treated with methylprednisolone and loratadine.Four weeks later,PLT rose from 84×109·L-1 to 136×109·L-1,skin rash disappeared,and renal function and general condition were improved.