Effect of rivaroxaban on preventing deep venous thrombosis after hip arthroplasty in elderly patients

Objective To investigate the preventive effect of rivaroxaban on deep vein thrombosis(DVT)after hip arthroplasty in the elderly patients.Methods A total of 145 elderly patients receiving primary hip arthroplasty were divided into two groups according to the postoperative administration.Rivaroxaban group(n=75)was given oral rivaroxaban 10 mg 6to 8hours after operation,and low molecular weight heparin(LMWH)group(n=70)was given subcutaneous injection of LMWH 0.4mL 12 to 24hours after operation,once a day,totally for 10 days.The DVT formation was detected by color Doppler ultrasound and the incidence of postoperative hemorrhage,postoperative drainage volume,platelet count,activated partial thromboplastin time coagulation test(APTT)and prothrombin time(PT)were compared between two groups after treatment for 10 days.Results DVT occurred in 5patients(6.7%),incision hemorrhage occurred in 2patients(2.7%),the postoperative drainage volume was(148.3±20.1)mL,platelet count was(223.0±13.1)×109/L,ATPP was(35.4±7.8)s and PT was(12.6±0.9)s in rivaroxaban group.DVT occurred in 6patients(8.6%),incision hemorrhage occurred in 3patients(4.3%),the postoperative drainage volume was(155.0±29.3)mL,platelet count was(219.5±12.2)×109/L,ATPP was(36.7±8.9)s and PT was(12.4±1.1)s in LMWH group,showing no significant difference in comparison with rivaroxaban group(P0.05).Conclusion Rivaroxaban has the similar effect on preventing the formation of DVT as LMWH,and oral administration of rivaroxaban has a good patient compliance.