2007•Zhonghua zhongliu fangzhi zazhiRequires access
Research progress in CD105 and its relation with tumors
Yajie Zhang
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Abstract
CD105(Endoglin) is a vessel endothelial cell marker and has been a hot spot in anti-cancer therapy.CD105 is a family receptor protein of transforming growth factor-β(TGF-β),mainly expresses in vessel endothelial cells adjusting the reaction of cells to TGF-β.CD105 mainly expresses in vessel endothelial cells in connnective tissue and tumor tissue.Immunohistochemistry studies have revealed that CD105 is strongly expressed in blood vessels of tumor tissues.Intratumoral microvessel density(MVD) determined by using antibodies to CD105 has been found to be an independent prognostic indicator,wherein increased MVD correlates with shorter survival,and it has been recognized as a promising vascular target.Compared to the past endothelial growth factors,CD105 is a better vessel endothelial cell marker factor,and it may be a new symbol and can be used as a new index for diagnosis and prognosis of tumor.It will be a useful method to estimate the progress and prognosis while using CD105 as a target molecule.