CYP3A4 Basic and Clinical Research Progress

Cytochrome P4503A4(CYP3A4) is a kind of main enzymes exist in human liver and intestinal, accounted for about 25% of the total adult liver CYP450 enzyme. About 50% of the Clinical medicine is through its metabolism, and its gene locus mutation associated with a variety of diseases, the study of CYP3A4 is grinding to a mature, has been gradually clarified the mechanism of interaction between the drug, it can be a variety of drugs competitive inhibition or induction, and affected by certain protein receptors in the regulation and control, can change the pharmacokinetics of drugs, enhance or reduce the effect, caused by individual differences, this also is the important cause of drug interactions. CYP3A4 gene polymorphism and genetic relationship oriented treatment, however, further studies are needed. This paper for CYP3A4 gene polymorphism, distribution and clinical disease and drug review summarizes the current research status.