Study on abnormal expression of the p73 genein acute lymphoblastic leukemia

ObjectiveTo investigate the effects of methylation p73 on pathogenesis of actue lymohoblastic leukemia. MethodsThe restriction endonuclease enzyme digestion combined with PCR was used to detect p73 gene and methylation in 42 patients with acute lymphoblastic leukemia. ResultsMethylation of p73 gene was found in 28.6%(12/42). Patients without methylation of p73 gene had a higher complete remission rate of first chemotherapy and a longer survival time than those with methylation of p73 gene. ConclusionMethylation of p73 gene probably plays a role in the pathogenesis of acute lymphoblastic leukemia and may have clinical significance in predicting prognosis of ALL.