The effect of limited fluid resuscitation on hemodynamics in rats with hemorrhagic shock

Objective To investigate the effect of limited fluid resuscitation on hemodynamics in rats with hemorrhagic shock.Methods The model of hemorrhagic shock was established in rats.Hemorrhagic shock was resuscitated by two different transfusion means: limited fluid transfusion and traditional transfusion.The hemodynamic changes at various time points,the volume of blood loss,blood/fluid transfusion at various period of shock and survival rate were compared between the two groups.Results At 120 min after the establishment of shock model,respiration and heart rate decreased while the mean arterial pressure(MAP) and the central venous pressure(CVP) were significantly increased in the limited fluid transfusion group than those in traditional resuscitation group(P0.05).During the early treatment of shock,the volume of blood loss in limited fluid resuscitation group was significantly lower than that of traditional resuscitation group(P0.05).The volume of blood/fluid transfusion was even lower during this period(P0.05) in limited transfusion group.The survival rates at 24 h and 72 h after shock in traditional resuscitation group were lower than those in limited fluid resuscitation group(P0.05).Conclusion Limited fluid resuscitation can significantly improve the hemodynamics of hemorrhagic shock rats,reduce the volume of blood loss and blood/fluid transfusion,and increase the survival.It is an ideal resuscitation for hemorrhagic shock.