The effect of genistein on the osteoporosis mice

Objective To investigate the impact of genistein on bone mineral density and biochemical indicator of bone metabolism in ovariectomized mice. Methods Reproduce the osteoporosis model of ovariectomized rats and receive estrogen therapy. After 8 weeks therapy, bone mineral density and biochemical indicator including serum alkaline phosphatase、calcium、phosphonium were measured. Results The bone mineral density of ovariectomized mice decreased significantly (P0.05),and it increased after 8 weeks therapy using genistein,and there were no significant difference between genistein and sham group. The level of serum alkaline phosphatase in genistein is higher than that in negative control group. Conclusions Genistein can improve and increase the bone mineral density in ovariectomized mice, having similar effect on nilestriol group.