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[Expression of endometrial leukaemia inhibitory factor gene in patients with unexplained infertility].

Xiaoyuan Guo, Qing Cheng, Y Wang

Abstract

OBJECTIVE: To investigate the expression of endometrial leukaemia inhibitory factor(LIF) gene in patients with unexplained infertility. METHODS: By a quantitative reverse transcription-polymerase chain reaction (RT-PCR), the expression of LIF gene on endometrium during mid-luteal phase was detected in 35 unexplained infertility (infertility group) cases and 20 infertile cases due to tubal obstruction or male factor (control group). RESULTS: The level of LIF mRNA expression on endometrium during mid-luteal phase in infertility group was 0.448 +/- 0.239, significantly lower than those in the control group (1.093 +/- 0.761, P < 0.01). CONCLUSIONS: Our findings suggested LIF might play an important role in the process of implantation. The decreased expression of LIF gene might be one of the major causes of unexplained infertility.

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Key concepts: Unexplained infertility, Infertility, Endometrium, Luteal phase, Andrology, Leukemia inhibitory factor, Gene expression, Medicine