Evaluation of the effect of acyclovir from different pharmaceutical corporations on peripheral blood cells of rabbit

OBJECTIVE To evaluate the effect of acyclovir from different corporations on peripheral blood cells of rabbit.METHODS Dividing 18 rabbits randomly into groups A,B,and C,6 rabbits per group.Group A(Acyclovir from corporation 1,30mg/kg),group B(Acyclovir from corporation 2,30mg/kg),group C(injecting normal saline,2ml per rabbit).Injecting slowly into the vein in ear edges of rabbits respectively,two times a day,morning and night,then,drawing blood after 4 and 8 days later respectively,injecting continuously in group B,drawing blood after 12,16 days later,inspecting changes of Hemoglobin(Hb),White blood cell(WBC),Platelet(Plt) and Ret iculocyte(Ret) in peripheral blood cells of rabbit.RESULTS After injection Acyclovir,comparing Hb、WBC、Plt and Ret in group A with group B and C,it could be found that both P0.05,which suggested there were no obvious differences between these groups.CONCLUSION There is no obvious damage to peripheral blood cells among different corporations and long-time injection.