Effect of Annaopingchongtang on cerebral edema and the expression of MMP-2/9 after intracerebral hemorrhage

Objective To observe the effect of Annaopingchongtang on brain water content and matrix metalloproteinase -2/9(MMP-2/9) after intracerebral hemorrhage(ICH) in rats.Methods Established cerebral hemorrhage model in rats by local injection of typeⅣcollagenase.The brain water content and the express of MMP-2/9 were observed after intracerebral hemorrhage at different time point(12 h,24 h,48 h,72 h,120 h) in different group(sham operation group,model group and therapy group).Results(1)Brain water content:compared with sham operation group,the brain water content in model group was higher group(P0.05),while the treatment group was lower than model group(P0.05).Compared with ICH model group,the brain water content of therapy group is decreased.(2) MMP-2/9 level:the expression of MMP-2 were decreased from 24 to 120 h(P0.05),and there were no difference at 12 h(P0.05),the expression of MMP-9 was decreased at 24 h,48 hand120 h(P0.05 ),there were no difference at 12 h and 72 h(P0.05 ).Conclusion Annaopingchongtang can be helpful for reducing the expression of MMP-2/9 and release brain edema in ICH rats.