Evaluate of the cardiac markers in the use of perioperative myocardial injury in patients undergoing coronary artery bypass graft surgery

Objective To evaluate the cardiac ma rk ers in the use of perioperative myocardial cell damage in patients undergoing co ronary artery bypass graft surgery (CABG). Methods 31 patients scheduled for CABG, Serum AST, L D H, CK, creatine kinase-MB isoenzyme(CK-MBmass), cardiac troponin T(cTnT) and m yo globin(Myo) were measured before induction of anesthesia, immediately after ICU, 6 h and 24 h after ICU. Results The median value of cardiac markers levels were all i n normal range before induction of anesthesia, and increased significantly immed iately after ～24 h after ICU. AST, CK-MBmass and cTnT levels reached peak valu e at 6 hour after ICU. Myoglobin peak value was immediately after ICU. LDH and CK levels reached the highest value 24 h after ICU. The degree of elevation was not different among CK, CK-MBmass and cTnT, which were significantly higher than th at of AST and LDH. CK-MBmass was related to the cTnT (r=0.57,P0.01). Conclusion cTnT is provided with the specificity of cardiac t roponins. CK-MBmass and cTnT are similar in the regular of release after CABG, b oth are as reliable perioperative monitoring indicators in patients undergoing C ABG, but cTnT is of larger diagnostic time window than CK-MBmass.