Anti-inflammatory, analgesic and antipyretic activities of lysine-aspirin

AIM : To study the anti-inflammatory, analgesic and antipyretic effects of lysine-aspirin (LSA) with rats and mice. METHODS: The anti-inflammatory effect was studied by rat paw edema, the analgesic effect by mouse acetic acid writhing and hot-plate methods and the antipyretic activity by fresh yeast method. RESULTS: LSA inhibited rat paw edema. The maximum inhibitory rate was up to 80%(P0.01). LSA inhibited both the primary and secondary inflammatory reactions and adjuvant arthritis in rats. The analgesic ED 50 in mice was 72±23 mg/kg measured by the method of acetic acid writhing. LSA had antipyretic effect on fever induced by fresh yeast in rats. The UD 50 of LSA in mice was 0.18±0.06 mmol / kg which was 2.4 folds of that of aspirin in moles. CONCLUSION: LSA had similar anti-inflammatory, analgesic and antipyretic effects to aspirin, whereas it had much less gastrointestinal lessions than aspirin in comparable doses.