Expression and Significance of Apoptosis-related Proteins Fas,FasL and bcl-2 in Colorectal Carcinomas

Objective To investigate the expression of apoptosis related proteins,Fas,FasL and bcl 2,and their clinical significances in colorectal carcinoma.Methods 80 samples of colorectal carcinoma tissue and 20 samples of normal colorectal tissue were examined with S P immunohistochemical staining.Results The positive rate of Fas protein in colorectal carcinoma tissues was significantly lower than that in normal colorectal tissues.The positive rate of Fas protein was significantly lower in colorectal carcinomas with lymph node involvement and hepatic metastasis than in tumors without metastasis,it was significantly lower in mediated differentiated and poorly differentiated tumors than in well differentiated tumors( P 0.05).The expression of Fas protein was closely related to Dukes stages ,histological types and differentiation grades( P 0.05).The positive rates of FasL and bcl 2 protein in colorectal carcinoma tissues were significantly higher than that in normal colorectal tissues.There was no significant difference between the expression of FasL,bcl 2 protein and Dukes stages,histological types and differentiation grades of tumors( P 0.05).The expression of Fas,FasL was not closely related to bcl 2 expression in colorectal carcinomas( P 0.05).Conclusion Many factors may regulate apoptosis.Fas/FasL system and bcl 2 may play an important role to inhibit apoptosis coordinatly in the occurrence and progression of colorectal carcinoma.