Effect of extracts of Gingko biloba leaves on the improvement of learning and memory disturbance in senile mice

Objective:To study the effect and mechanism of extracts of Gingko biloba leaves(EGB)on the improvement of learning and memory disturbance in senile mice.Methods Thirty-three male mice were randomly divided into 3 groups,11 mice in each group.Mice in model group were injected with D-galactose(300 mg/kg BW) by celiac injection once a day,and the mice in treatment group were injected with D-galactose(300 mg/kg BW)and EGB(15 mg/kg BW) at the same time.The mice in normal group were injected with the same volume of physiological saline solution.After treatment for 6 weeks,the learning and memory ability of mice in each group were determined with Y-maze test and step-down test,and the monoamine oxidase(MAO) activity in liver and brain tissue was tested at the same time.During the test,the celiac injection was stopped.Results:The ability of learning and memory in treatment group was significantly higher than that in model group(P0.05 or P0.01).Conclusion:EGB could improve learning and memory disturbance in senile mice and MAO probably plays an important role in the metabolic process.