Dissolution behavior in vitro and pharmacokinetic behavior in beagle dogs of tretinoin with the self-emulsifying formulation

Objective To investigate the content assay method and dissolution behavior in vitro and pharmacokinetic behavior in beagle dogs of tretinoin with the self-emulsifying formulation.Method The plasma concentrations and the content of the preparation were determined by HPLC.The dissolution behavior in vitro and pharmacokinetic behavior in vivo were evaluated when compared with the commercial capsules.Result The area under the curve (AUC) was significantly higher in the tretinoin self-emulsifying formulation group((3 048.0 mg·h·L~(-1))) than that in the commercial capsule group((1 826.0 mg·h·L~(-1))).Also,t_(max) was smaller in the self-emulsifying formulation group((1.25 h)) when compared with the market products ((2 h)) and the dissoluted amount from self-emulsifying formulations in water for (15 min) was much higher (more than 80%)than that of the market products( less than 5%).Conclusion The self-emulsifying drug delivery systems can increase drug dissolution in vitro and absorption in vivo significantly.