Progress of the Relative Genes to Invasion and Metastasis of Gastric Cancer

Gastric cancer is a kind of malignant tumor with the highest attack rate in China.The reason that it causes the high death rate lies in the wide invasion and metastasis.The invasion and metastasis of gastric cancer is a complicated active process related to multiple factors and multiple genes.Many mechanisms are not very clear at the present,but latest studies show that angiogenesis in the stroma of tumor and degradation of extracellular matrix are the important procedures involved in metastasis and invasion of malignant tu- mor.With the development of molecular biology,the studies on these two procedures become a hotspot on genic level.We now find many genes such as VEGF,MMP which regulate the angiogenesis in the stroma and degradation of extracellular matrix in different ways, thus cause the invasion and metastasis of gastric cancer.