Pharmacokinetics and Bioavailability of Granisetron Hydrochloride Tablets in Healthy Volunteers

The pharmacokinetics of granisetron hydrochloride orally disintegrating tablets (test preparation) and its related bioavailability to granisetron hydrochloride tablets (reference preparation) are discussed. According a single dose crossover design,20 healthy volunteers were administrated with 1mg of test and reference preparations. The plasma concentrations were determined by HPLC-fluorescence detector. The pharmacokinetic parameters of the test and reference preparations were as follows:cmax (3.32±0.93) and (3.20±0.86) ng/ml,tmax (1.65±0.52) and (1.88±0.86) h,t1/2 (6.16±0.90) and (6.22±0.81) h,AUC0→t (19.50±8.10) and (19.70±7.78) ng·h·ml-1,AUC0→∞ (20.90±9.11) and (21.10± 8.57) ng·h·ml-1. The relative bioavailability of the test preparation was (99.8±15.3)%. The result showed that the two preparations were bioequivalent.