2008•Journal of Medical ForumRequires access

Promoter Methylation of RASSF1A Gene in Gastric Carcinoma

Linghua Yu

Abstract

Objective To determine RASSF1A methylation in the cancer and adjacent cancer tissues.Methods Sample primary tumors were collected from 40cases of primary gastric cancer.Adjacent cancer tissues and carcinoma tissues were selected from every subjects.Methylation of RASSF1A gene promoter was detected using methylation-specific PCR(MSP).Results Promoter methylation of RASSF1A could be detected in 26cases(65.0%) in gastric carcinoma,while only one found in adjacent cancer tissues(2.5%)(P0.05).Conclusion RASSF1A methylation was the possible mechanism of carcinogenesis of gastric carcinoma and might be a frequent molecular event in gastric carcinoma.Thus,RASSF1A methylation could serve as a useful biomarker to screen the high-risk subjects and to make early diagnosis for gastric carcinoma.

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Key concepts: Methylation, Cancer, Carcinogenesis, Cancer research, DNA methylation, Carcinoma, Biology, Biomarker