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2013•China Medicine and PharmacyRequires access

Rapid determination of isoniazid tablet by near infrared spectroscopy

Zhang Li

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Abstract

Objective To investigate the application of near infrared spectroscopy(NIRS) on isoniazid tablet determination. Methods Applied partial least squares(PLS)to construct a calibrate model.We used analysis of variance to select suitable wavelength range, used principal component analysis to group the sample as calibration set and validation set,used cross-validation to choose the optimum factors. Results Using the PLS model to determinate9 isoniazid tablet samples,compared the NIRS results with HPLC,the relative error is less than ±0.8%.It means that this method is accurate. Conlusion It is feasible to applied NIRS on isoniazid tablet rapid determination.There have a good prospect on process control in pharmaceutical industry and rapid quality detection.

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What this paper is about

Objective To investigate the application of near infrared spectroscopy(NIRS) on isoniazid tablet determination. Methods Applied partial least squares(PLS)to construct a calibrate model.We used analysis of variance to select suitable wavelength range, used principal component analysis to group the sample as calibration set and validation set,used cross-validation to choose the optimum factors. Results Using the PLS model to determinate9 isoniazid tablet samples,compared the NIRS results with HPLC,the relative error is less than ±0.8%.It means that this method is accurate. Conlusion It is feasible to applied NIRS on isoniazid tablet rapid determination.There have a good prospect on process control in pharmaceutical industry and rapid quality detection.

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Available abstract

Objective To investigate the application of near infrared spectroscopy(NIRS) on isoniazid tablet determination. Methods Applied partial least squares(PLS)to construct a calibrate model.We used analysis of variance to select suitable wavelength range, used principal component analysis to group the sample as calibration set and validation set,used cross-validation to choose the optimum factors. Results Using the PLS model to determinate9 isoniazid tablet samples,compared the NIRS results with HPLC,the relative error is less than ±0.8%.It means that this method is accurate. Conlusion It is feasible to applied NIRS on isoniazid tablet rapid determination.There have a good prospect on process control in pharmaceutical industry and rapid quality detection.

Key concepts: Medicine, Isoniazid, Calibration, Partial least squares regression, Near-infrared spectroscopy, Principal component analysis, Statistics, Mathematics

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