2002•Zhongguo yaofangRequires access

Pharmacokinetic Analysis for Lactosaminated Recombination Human Growth Hormone and Recombination Human Growth Hormone by Radioimmunoassay

Ze-Lian Chen, Pang Qijie

Abstract

OBJECTIVE:To study the pharmacokinetics of L-rhGH and rhGH in mice.METHODS:The concertrations of L-rhGH and rhGH in plasma and liver were measured by radioimmunoassay.RESULTS:After intravenous injection,there were significant differences between L-rhGH and rhGH in pharmacokinetic parameters.The Cmax of L-rhGH in the liver was higher than that of rhGH but the T1/2 of L-rhGH was only 17.9% of T1/2 of rhGH;the Cmax of L-rhGH in plasma was lower than that of rhGH and the T1/2 was shorter.CONCLUSION:L-rhGH reveals the pharmacokinetic characteristics which fits in with the physiology of human body.

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Key concepts: Radioimmunoassay, Pharmacokinetics, Cmax, Human growth hormone, Endocrinology, Internal medicine, Growth hormone, Medicine