Number changes of mucosal immunity-associated cells in small intestine of goats which naturally infected by Moniezia benedeni

In order to study the number changes of mucosal immunityassociated cells in small intestine of goats which naturally infected by Moniezia benedeni(contract group),the distribution and number of intraepithelial lymphocytes(IELs),plasma cells,goblet cells and eosinophile granulocytes(EOS)were investigated by the histological and histochemical methods,and then compared with control group.The results showed that the number of these four kinds of cells in the contracted group were all significantly higher than control group,and the increased rate of IELs was 169.11% in duodenum,230.38% in jejunum and 233.42% in ileum(P0.01),the increased rate of EOS was 116.78% in duodenum,123.87% in jejunum and 164.51% in ileum(P0.01),the increased rate of plasma cells was 127.34% in duodenum,72.97% in jejunum and 328.26% in ileum(P0.01),the increased rate of goblet cells was 33.40% in duodenum,41.42% in jejunum and133.17% in ileum.In addition,the number of IELs and goblet cells all decreased substantially from duodenum to ileum in both contracted and control groups,otherwise,the number of EOS increased from duodenum to ileum in two groups,and the number of plasma cells increased from duodenum to ileum in contracted group only but increased from duodenum to jejunum and decreased from jejunum to ileum in control group.Besides,the number of these four kinds of cells had obvious differences in the all small intestine of control group(P0.01);The number of goblet cells,plasma cells and EOS also had obvious differences in the all small intestine of contracted group(P0.01),but the number of IELs only had difference in jejunum and ileum(P0.05).The results suggested that the cellular and humoral immunity function were respectively increased trough the proliferation of IELs and plasma cells which were special mucosal immunity-associated cells,and also trough the proliferation of non-special mucosal immunity-associated cells(EOS and goblet cells)enhanced the anti-infection.It is thus clear that goat could strength the local immune function by the proliferation of relative cells to monitor the immune escape of parasite.