Relation of the expression of KiSS-1,GPR54,MMP-9 and invasion and metastasis of non-small cell lung cancer

Objective:To study the expression of KiSS-1,GPR54 and MMP-9 in non-small cell lung cancer tissues and the relation with the invasion and metastasis.Methods: Total of 98 tumor tissue of non-small cell lung cancer and 30 normal tissue 3 cm off the tumor region were studied.The expression of KiSS-1,GPR54 and MMP-9 was evaluated by immunohistochemical technique(S-P method).Results: The positive expression rate of KiSS-1 in non-small cell lung cancer tissue was significantly lower than in normal lung tissue(P0.01);meanwhile the positive expression rate of MMP-9 in non-small cell lung cancer tissue was significantly higher than in normal lung tissues(P0.01).The positive expression rate of KiSS-1 in non-small cell lung cancer with metastasis in lymph node was significantly lower than that of absence of metastasis in lymph node(P0.01);the positive expression rate of GPR54,MMP-9 in non-small cell lung cancer with metastasis in lymph node was significantly higher than that of absence of metastasis in lymph node(P0.05).The expression of KiSS-1 and GPR54,MMP-9 in non-small cell lung cancer tissue showed a significant negative correlation.onclustion: Low KiSS-1 gene expression and high expression of GPR54,MMP-9 may play an important role in the invasion and metastasis of non-small cell lung cancer.