Research Progress about the Molecular Structure and Tissue Distribution and Regulation of TREK-1 and the Role of Anti-epileptic

Potassium channel is the largest and most complex family of ion channels.S o far,more than 70 kinds of potassium ion channel subtypes have been cloned,in which the two pore domain potassium channels are discovered in recent years.They are different from traditional single potassium ion channel such as voltage dependent potassium channel,calcium activated potassium channel,and inward rectifier potassium channels etc in structure.Two pore domain potassium channel,with four transmembrane segments,formed a unique domain two channel structure,mainly mediatesbackground potassium current.Due to this characteristic,two pore domain potassium channel participates and maintains resting membrane potential.Therefore,it becomes the focus of attention.In recent years,the most studiedTREK- 1expresses in almost every cell of the body.It can be controlled by intracellular acidity,membrane stretch,polyunsaturated fatty acid,temperature,and receptor coupled second messenger system.And it regulates cell excitability,participates in a series of physiological and pathological process,and is closely related to nervous system diseases such as epilepsy.This article makes a brief introduction.