2001•Shanghai yixueRequires access

The difference and significance between cag I and cag II distribution in Chinese H. pylori strains

Gong Yanfang

Abstract

Objective To investigate the difference of cag Ⅰ and cag Ⅱ in distribution of Helicobacter pylori (Hp) isolated from Chinese patients, and its relationship to gastroduodenal diseases. Methods cag Ⅰ (170 bp) and cag Ⅱ (597 bp) in cag pathogenicity island were amplified by polymerase chain reaction (PCR) in 107 Hp strains from Chinese patients. Results The amplicom to cag Ⅰ was positive in 93 strains, and fragment to cag Ⅱ was positive in 74 strains, cag Ⅰ or cag Ⅱ was positive alone in 27 or 8 strains respectively. The distribution of cag Ⅰ and cag Ⅱ in Chinese Hp strains was different ( P 0.01). Conclusion The positivity of cag Ⅰ is obviously higher than that of cag Ⅱ in Chinese Hp strains, especially in Hp infected chronic gastritis.

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Key concepts: Helicobacter pylori, Polymerase chain reaction, Medicine, Microbiology, Gastritis, Significant difference, Biology, Gene