2012•Chinese Journal of Gastroenterology and HepatologyRequires access
The significance of perinuclear anti-neutrophil cytoplasmic antibodies in diagnosis of ulcerative colitis
Sheng Jianqiu
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Abstract
Objective To study the sensibility and specificity of detection of perinuclear anti-neutrophil cytoplasmic antibodies(pANCA) in diagnosis of ulcerative colitis(UC).Methods Serum samples were obtained from 51 patients with ulcerative colitis(UC),15 patiens with Crohn's disease(CD) and 30 patients without intestinal disease as control.pANCA was detected by indirect immunofluorescence assay.Results The sensibility and specificity of p-ANCA in UC patients were 67.75% and 95.56% respectively,but the positive of pANCA in CD patients was 13.33%(2/15).No patients was positive in control group(P0.05).Conclusion Serum pANCA in patients with UC shows a moderately sensibility and a high specificity,it is useful for the diagnosis of UC and differentiation between UC and CD.