Effects of Low Dose Estrogen on Prevention and Treatment of Postmenopausal Osteoporosis

Objective:To study the effect of different doses estrogen therapy on prevention and treatment of postmenopausal osteoporosis.Method:90 cases postmenopausal women were randomly divided into 3 groups:Group A(30 cases) received Premarin 0.3 mg + Cahrate 1g per day;Group B(30 cases) received Premarin 0.3 mg + Cahrate 1g per day;Group C(35 cases) received placebo + Cahrate 1g per day.Before the drug administration and 1year after the treatment,the bone mineral density(BMD)of hip bone was measured by quantitative ultrasound measurement,the endometrium and breast tenderness were recorded by B-ultrasound,and the serum indexes of bone metabolism were recorded.Result:Bone pain of patients three groups has improved the varying degree.The broadband attenuation and the speed of sound(SOS) in group A and B maintained no significant difference between before and after treatment.Those in group C were significantly different between before and after treatment(P0.05).Ratio of urine calcium/ creatinine and hydroxyproline/ creatinine in group A and B were significantly different between before and after treatment(P0.05).Other observation indicators such as:breast B-ultrasound,endometrial B-ultrasound,vaginal exfoliated cells for cancer were no significant differences in three groups.Conclusion:Low dose of estrogen can prevent postmenopausal osteoporosis effectively and safely.