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Significance of Detecting MMP-9 in the Cerebrospinal Fluid of Patients with Tuberculous Meningitis

Ye Yixiu

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Abstract

Matrix metalloproteinases-9(MMP-9) may contribute to the destruction of blood-brain barrier.The aim of this study was to detect the levels of MMP-9 in cerebrospinal fluid(CSF) to evaluate the significance of its changes in the pathogenesis of tuberculous meningitis.An enzyme-linked immunosorbent assay(ELISA) was used to detect MMP-9 in the CSF from patients with tuberculous meningitis(n=12),virus meningitis(n=9) and the controls(n=5).The results showed that MMP-9 in CSF of patients with tuberculous meningitis was significantly higher.The central nervous system complication was related to MMP9 in CSF of patients with tuberculous meningitis.The levels of MMP-9 in CSF may be useful for the diagnosis and prognosis of tuberculous meningitis.

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What this paper is about

Matrix metalloproteinases-9(MMP-9) may contribute to the destruction of blood-brain barrier.The aim of this study was to detect the levels of MMP-9 in cerebrospinal fluid(CSF) to evaluate the significance of its changes in the pathogenesis of tuberculous meningitis.An enzyme-linked immunosorbent assay(ELISA) was used to detect MMP-9 in the CSF from patients with tuberculous meningitis(n=12),virus meningitis(n=9) and the controls(n=5).The results showed that MMP-9 in CSF of patients with tuberculous meningitis was significantly higher.The central nervous system complication was related to MMP9 in CSF of patients with tuberculous meningitis.The levels of MMP-9 in CSF may be useful for the diagnosis and prognosis of tuberculous meningitis.

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Available abstract

Matrix metalloproteinases-9(MMP-9) may contribute to the destruction of blood-brain barrier.The aim of this study was to detect the levels of MMP-9 in cerebrospinal fluid(CSF) to evaluate the significance of its changes in the pathogenesis of tuberculous meningitis.An enzyme-linked immunosorbent assay(ELISA) was used to detect MMP-9 in the CSF from patients with tuberculous meningitis(n=12),virus meningitis(n=9) and the controls(n=5).The results showed that MMP-9 in CSF of patients with tuberculous meningitis was significantly higher.The central nervous system complication was related to MMP9 in CSF of patients with tuberculous meningitis.The levels of MMP-9 in CSF may be useful for the diagnosis and prognosis of tuberculous meningitis.

Key concepts: Tuberculous meningitis, Medicine, Cerebrospinal fluid, Meningitis, Pathogenesis, Matrix metalloproteinase, Viral meningitis, Pathology

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Significance of Detecting MMP-9 in the Cerebrospinal Fluid of Patients with Tuberculous Meningitis — Research Paper | ScholarLens