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Synthesis of 2-Amino-5-nitrophenol

Yan Li

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Abstract

Amino 5 nitrophenol was synthesized using o aminophenol and urea as raw materials through cyclocondensation,nitration and alkaline hydrolysis in turn.Factors influencing the reactions were studied.The overall yield was 80%.The optimum conditions are as follows.In cyclocondensation, o aminophenol and urea (molar ratio 1.00∶1.05) reacted at 115 ℃ for 1.5 h.Nitration was carried out at 40 ℃ for 2 h with HNO\-3 and H\-2SO\-4,and alkaline hydrolysis at 105 ℃ for 2.5 h.The product was characterized by IR.This new method, o aminophenol urea method,is facile,of low cost and lacking in wastes.The overall yield of conventional process is only 36%-53%.

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Amino 5 nitrophenol was synthesized using o aminophenol and urea as raw materials through cyclocondensation,nitration and alkaline hydrolysis in turn.Factors influencing the reactions were studied.The overall yield was 80%.The optimum conditions are as follows.In cyclocondensation, o aminophenol and urea (molar ratio 1.00∶1.05) reacted at 115 ℃ for 1.5 h.Nitration was carried out at 40 ℃ for 2 h with HNO\-3 and H\-2SO\-4,and alkaline hydrolysis at 105 ℃ for 2.5 h.The product was characterized by IR.This new method, o aminophenol urea method,is facile,of low cost and lacking in wastes.The overall yield of conventional process is only 36%-53%.

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Available abstract

Amino 5 nitrophenol was synthesized using o aminophenol and urea as raw materials through cyclocondensation,nitration and alkaline hydrolysis in turn.Factors influencing the reactions were studied.The overall yield was 80%.The optimum conditions are as follows.In cyclocondensation, o aminophenol and urea (molar ratio 1.00∶1.05) reacted at 115 ℃ for 1.5 h.Nitration was carried out at 40 ℃ for 2 h with HNO\-3 and H\-2SO\-4,and alkaline hydrolysis at 105 ℃ for 2.5 h.The product was characterized by IR.This new method, o aminophenol urea method,is facile,of low cost and lacking in wastes.The overall yield of conventional process is only 36%-53%.

Key concepts: Nitration, Urea, Chemistry, Yield (engineering), Molar ratio, Hydrolysis, Alkaline hydrolysis, Raw material

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