Therapeutic Effect of Oxymatrine on Patients with Severe Chronic Hepatitis B

[Objective] To observe the clinical effect and adverse effect of oxymatrine in treating patients with severe chronic hepatitis B(CHB).[Methods] Eighty Patients with CHB were randomly divided into two groups.The control group(n=40)was only received liver-protective drugs and supportive therapy,while the treatment group(n=40)was administrated oxymatrine plus liver-protective drugs and supportive therapy for 8 weeks.Liver function and hepatitis B virus(HBV)replication markers such as HBeAg and HBV DNA were detected before and after treatment.The symptom,physical sign and adverse effect were observed.[Results] The titer of HBeAg and copies of HBV DNA in the treatment group were significantly lower than those in the control group(P0.05).The negative-conversion rate of HBV replication markers was significantly different between the control group and the treatment group(28.6% vs 5.3%,12.5.0% vs 2.5%,P0.05).The levels of AST,ALT and TBil were significantly lower in the treatment group than those in the control group(P0.05).The adverse reaction was only mild gastrointestinal reaction.[Conclusion] Oxymatrine can inhibit HBV replication and improve liver function.It is an effective Chinese drug preparation for the treatment of severe CHB and can increase cure rate.