Randomized Controlled Trial of Chinese Herbal Compound Recipe of Changjiling for Diarrhea-predominant Irritable Bowel Syndrome

Objective To investigate the therapeutic effect of Chinese herbal compound recipe of Changjiling for diarrhea-predominant irritable bowel syndrome(IBS-D).Methods Eighty IBS-D patients were randomized into treatment group(N = 54) and control group(N = 26).The treatment group was given Changjiling orally,and the control group was given Pinaverium Bromide and Deanxit orally.The treatment covered 4 weeks,and the follow-up lasted half a year.The therapeutic effect was evaluated after treatment,and the scores of symptoms and life of quality(QOL) were counted before and after treatment in both groups.Results After treatment for 4 weeks,the total effective rate was 83.33% in the treatment group and was 61.54% in the control group,the difference being significant(P 0.05).The scores of symptoms were improved in both groups after treatment(P 0.05 or P 0.01 compared with those before treatment).Except for abdominal pain and emotional upset,the scores of symptoms were obviously improved in the treatment group as compared with those in the control group(P 0.05).The results of follow-up showed that treatment group had better therapeutic effect than the control group(P 0.05),and most of the symptoms were obviously improved in the treatment group(P 0.05).The score of most QOL items was improved in the treatment group after treatment and follow-up(P 0.05 or P 0.01 compared with that before treatment),and the improvement was superior to that in the control group(P 0.05).Conclusion Chinese herbal compound recipe of Changjiling exerts better short-term and long-term therapeutic effect for diarrhea-predominant irritable bowel syndrome than western medicine,and the effect on improving QOL is satisfactory.