The expression of survivin and its relationship with the expression of bcl-2 and bax protein in glioma

Objective:To study the expression of apoptosis related gene survivin and its relationship with the expression of bcl-2,bax protein in glioma.Methods:Expression of survivin,bcl-2 and bax protein was detected by immunohistochemical method(SP) in 40 cases of glioma,and compared with those in 10 cases of normal brain tissue.The correlation between them was analyzed.Results:The expression rate(42.5%) of survivin protein in glioma was much higher than that(0%) in normal brain tissue(P0.05).The positive ratio was significantly higher in Ⅲ(50.0%) and Ⅳ(80.0%) grade than in Ⅰ～Ⅱ(16.7%) grade(P0.01).Expression of bcl-2 and bax protein was positively and negatively correlated with expression of survivin protein respectively.Conclusion:Survivin may play an important role in pathogenesis of glioma,apoptosis related gene bcl-2 may have a synergic role and bax have an antagonistic role with survivin gene in formation and progression of glioma.