Shu Chen
Abstract
(±)-2 (2 Chlorophenyl) 2 (methylamine)cyclohexanone was resolved with L (+) and D (-) tartaric acid as the resolving agent to give S (+) and R (-) ketamine free base with optic activation,the free base was salified to S (+) ketamine hydrochloride and R (-) ketamine hydrochloride.
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(±)-2 (2 Chlorophenyl) 2 (methylamine)cyclohexanone was resolved with L (+) and D (-) tartaric acid as the resolving agent to give S (+) and R (-) ketamine free base with optic activation,the free base was salified to S (+) ketamine hydrochloride and R (-) ketamine hydrochloride.
Key concepts: Chemistry, Hydrochloride, Free base, Ketamine hydrochloride, Methylamine, Cyclohexanone, Ketamine, Organic chemistry