2013•Henan yixue yanjiuRequires access
Effect of atorvastatin on lung oxidative damage by acute paraquat poisoning
Guoyu Duan
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Abstract
Objective: To study the effects of atorvastatin in protect the lung injury induced by acute paraquat poisoning in rats.Methods: Forty SD rats were divided into four groups: control,paraquat poisoning model,treat with low dosage and high dosage atorvastatin group.Paraquat poisoning model group and the treatment groups were given paraquat 80 mg·kg-1 gavage for one time;The treatment groups were respectively given atorvastatin 20 mg·kg-1·d-1,40 mg·kg-1·d-1 gavage for 7 days.The animals were anesthetized and got the lung tissue,then observed the pathological changes by HE staining,and study the changes of SOD and GSH-PX.Results: The result of HE Staining: The lung injury of paraquat poisoning lung is obviously serious than other groups.Treatment groups reduce the lung injury.SOD,GSH-PX determination results: The level of SOD,GSH-PX were significantly lower in poisoning group than those in control group(P0.05).After seven days treatment,a significant increasing occurred in SOD,GSH-PX level with a dose-dependent manner(P0.05).Conclusion: Atorvastatin significantly attenuated lung injury induced by acute paraquat poisoning.Its mechanism might be related to the activity increase of SOD、GSH-PX.